P3 (Hansman)

Binding Adaptability of Caliciviruses to Histo-Blood Group Antigens

The purpose of this project is to provide a detailed analysis of calicivirus and histo-blood group antigens interactions. We will work closely with other groups that can provide expertise in X-ray crystallography (P1, P2), NMR (P6), mass spectrometry (P8) and glycan design (P7). To this end, we will describe possible ways in which caliciviruses utilize their virus capsid evolution and adapt different glycan binding profiles.

 

P3 Hansman's Group Webpage